Prescribed by independent licensed providers. Coached and monitored by OneTwenty. Started low, adjusted on your data, and rechecked against your blood work every quarter.
A medication is never the first move and never a one-time order. It sits inside the same measure, adjust, retest loop as everything else in your protocol.
Your first panel sets the starting point. Nothing is prescribed before an independent licensed provider has seen your numbers.
Your coach and the AI assistant turn the panel into a plan: lifestyle first, then supplements. If a medication might help, you are referred to independent licensed providers who decide.
You start at the lowest dose. Weight, device signals and how you feel are reviewed, and the dose moves only when the evidence says it should.
The biomarkers tied to your medication are added to your next lab panel, so every dose decision is checked against blood work.
Titration
Every medication starts at its lowest dose. From there the dose only steps up when the data says it should: the weight and device signals your coach and prescriber see each month, and the blood work that comes back each quarter.
Enclomiphene is a selective estrogen receptor modulator that stimulates the body's natural testosterone production in men, supporting hormone balance, fertility, energy and metabolic health.
Tracks Total TestosteroneFree TestosteroneBioavailable Testosterone +3 Learn More Cream
GHK-Cu is a naturally occurring copper peptide applied to the skin. It is used in topical formulations for skin appearance and repair support.
Tracks hs-CRP (C-Reactive Protein)Ferritin Learn More Injection
Glutathione Injections deliver the body's master antioxidant directly into the bloodstream to support detoxification, immune health and protection against oxidative stress.
Tracks Liver Enzyme ALTAspartate Aminotransferase (AST)hs-CRP (C-Reactive Protein) +3 Learn More Nasal Spray
Glutathione Nasal Spray delivers the body's master antioxidant through the nasal mucosa to support detoxification, immune function and cellular protection.
Tracks Liver Enzyme ALTAspartate Aminotransferase (AST)hs-CRP (C-Reactive Protein) +3 Learn More Injection
HCG mimics LH to stimulate the testes, helping maintain natural testosterone production and fertility. Often used alongside TRT.
Tracks Total TestosteroneFree TestosteroneBioavailable Testosterone +3 Learn More Oral Tablet
Metformin is an oral medication used to improve the body's response to insulin and lower blood sugar. It has been in clinical use for decades and is also studied for its effects on metabolic health.
Learn More Injection
NAD+ injections deliver a coenzyme directly into the bloodstream to support cellular energy production, DNA repair, cognitive function and healthy aging.
Tracks hs-CRP (C-Reactive Protein)HomocysteineFasting Glucose +3 Learn More Nasal Spray
NAD+ Nasal Spray delivers Nicotinamide Adenine Dinucleotide through the nasal mucosa for needle-free cellular energy support and cognitive function.
Tracks hs-CRP (C-Reactive Protein)HomocysteineFasting Glucose +3 Learn More Nasal Spray
Oxytocin Nasal Spray delivers the body's natural bonding hormone through the nasal mucosa to support emotional connection, social confidence and stress resilience.
Tracks SodiumBlood Pressure (BP) Learn More Injection
PT-141 is a melanocortin receptor agonist that acts on the brain to help increase sexual desire and arousal in both men and women.
Tracks Total TestosteroneBlood Pressure (BP) Learn More Injection
Compounded Semaglutide is a GLP-1 receptor agonist that supports weight loss and metabolic health through appetite regulation and blood sugar control.
Tracks Hemoglobin A1cFasting GlucoseLDL Cholesterol +3 Learn More Oral Tablet
Sildenafil is a fast-acting PDE5 inhibitor that increases blood flow to support firm, reliable erections when taken before sexual activity.
Tracks Apolipoprotein B (ApoB)Lipoprotein (a)Hemoglobin A1c +3 Learn More Injection
Sermorelin is a GHRH analogue that stimulates the pituitary to produce and release growth hormone, supporting lean muscle, fat metabolism, sleep quality and recovery.
Tracks Fat-to-Muscle RatioTotal TestosteroneSHBG +3 Learn More Oral Tablet
Tadalafil is a long-acting PDE5 inhibitor that increases blood flow to support firm, lasting erections, with effects that can last up to 36 hours.
Tracks Apolipoprotein B (ApoB)Lipoprotein (a)Hemoglobin A1c +3 Learn More Injection
Tirzepatide is a dual GIP and GLP-1 receptor agonist used in weight management. It acts on two hormones involved in appetite and blood sugar regulation. Prescribed and adjusted by an independent licensed provider, based on your quarterly lab results.
Tracks Hemoglobin A1cFasting GlucoseLDL Cholesterol +3 Learn MoreNo treatments found.
Add-on biomarkers
When your prescriber writes one of these medications, the markers it affects are added to your quarterly panel. These are the 24 biomarkers behind the medications on this page, and how many of them each one monitors.
Independent licensed providers. They make every clinical decision and are responsible for evaluation, diagnosis and prescribing. OneTwenty is a health optimization membership, not a medical practice, and does not direct their judgment.
No. OneTwenty escalates gradually: lifestyle changes first, then supplements, and only then medication if your data and a provider support it. Most of what the membership does never involves a prescription.
You begin at the lowest starting dose. Each month your prescriber looks at your monitored data, such as weight, blood pressure and device signals, and adjusts if needed. Each quarter the biomarkers tied to your medication are rechecked in your lab panel before any larger change.
Every medication on this page lists the markers your prescriber watches while you take it. When you are prescribed one, those markers are added to your quarterly panel so the effect on your blood work, not just the scale, guides the next step.
Some are. A compounded medication is only used when the commercially available product is unavailable or when your prescriber determines there is a clinically significant difference for you. Each medication page says whether this applies.
OneTwenty membership is available in 49 states. Whether a specific medication can be prescribed to you depends on your prescriber and the rules in your state, and some medications on this page are marked coming soon.
Your labs decide whether any of this is for you.
Get startedLifelong Optimization
Founding pricing ends at public launch
Frequently Asked Questions
Answers on setup, scale, and support to remove blockers.
Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.
OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.
What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.
Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.
If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.
Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.
No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.
We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.
Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.
One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.
Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.
Here is why:
The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."
The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.
Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.
We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.
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