Biomarkers we prioritize on this medication
Desire has a hormonal floor worth checking
View marker →Elevated prolactin suppresses desire directly
View marker →Thyroid state affects libido in men and women
View marker →Low iron is a common cause of low libido
View marker →Transient rise can be seen post-dose
View marker →Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.
Medicine information
PT-141 is a melanocortin receptor agonist that acts on the brain to help increase sexual desire and arousal in both men and women.
Commonly prescribed for
Active ingredients
Bremelanotide Acetate
A subcutaneous injection taken ahead of activity, not on a daily schedule. Refrigerate and follow the pharmacy label. Nausea and facial flushing are commonly reported shortly after a dose. Dispose of needles in a sharps container.
Nausea is the most commonly reported effect and is the most common reason people stop the medication; anti-nausea treatment before a dose is sometimes used. Flushing, injection site reactions, headache and vomiting are also commonly reported. Less commonly reported is focal hyperpigmentation — patches of darkened skin on the face, gums or breasts — which is more frequent with darker skin tones and with frequent dosing, and which may not fully resolve after stopping. Every dose produces a temporary rise in blood pressure and a small fall in heart rate, peaking two to four hours after the dose and generally returning to baseline within twelve hours. A single case of acute hepatitis has been reported.
Bremelanotide is not prescribed to anyone with uncontrolled high blood pressure or with known cardiovascular disease, and it is not recommended for anyone at high cardiovascular risk. It is not used in pregnancy. Labelling limits it to one dose in any 24-hour period and no more than eight doses per month, because more frequent use increases the blood pressure effect and the risk of skin darkening. It is used cautiously with severe kidney or liver impairment, and darkening of the skin is treated as a reason to reconsider treatment. The FDA-approved product is indicated only for premenopausal women with acquired, generalised hypoactive sexual desire disorder; any other use is off-label and is prescribed at an independent clinician's discretion.
PT-141 (bremelanotide) is a melanocortin receptor agonist. It activates melanocortin receptors in the central nervous system that are involved in sexual response. Rather than acting on the vascular system to affect blood flow, it influences the neural pathways tied to sexual desire and arousal, which is why it can be effective for a broader range of causes and is taken ahead of anticipated activity.
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