Biomarkers we prioritize on this medication
Confirms the testes are still responding
View marker →HCG raises aromatisation more than TRT alone
View marker →Suppressed on TRT; HCG substitutes for LH
View marker →Rises when testosterone rises, from any source
View marker →Helps interpret whether free testosterone is adequate
View marker →Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.
Medicine information
HCG mimics LH to stimulate the testes, helping maintain natural testosterone production and fertility. Often used alongside TRT.
Commonly prescribed for
Active ingredients
Human Chorionic Gonadotropin (hCG)
A subcutaneous injection, typically several times per week. Refrigerate after reconstitution and follow the pharmacy label. Your prescriber sets the dose and schedule. Dispose of needles in a sharps container.
Commonly reported effects are injection site pain and reaction, headache, tiredness, restlessness and mood changes. Gynaecomastia and breast tenderness are reported and are driven by the rise in oestradiol that follows hCG stimulation. A rise in red blood cell concentration and fluid retention with swelling are also reported, and both are usually addressed by adjusting the dose. Labelling notes sporadic reports of testicular tumours in young men treated with hCG, without established causation, and that hCG can interfere with laboratory measurement of gonadotropins, particularly LH.
hCG is not prescribed to anyone with prostate cancer or another androgen-dependent tumour, to anyone with early or precocious puberty, or to anyone who has had an allergic reaction to hCG. Labelling advises caution in cardiac or kidney disease, epilepsy, migraine and asthma, because the fluid retention that follows androgen stimulation can worsen those conditions. It is not used in women who are or may become pregnant unless prescribed for that purpose by a fertility specialist.
HCG (Human Chorionic Gonadotropin) closely mimics luteinizing hormone (LH), binding to LH receptors on the Leydig cells in the testes. This stimulates the testes directly to continue producing testosterone and supports spermatogenesis, even when the body's own LH production is suppressed, such as during testosterone replacement therapy. This helps maintain testicular volume and fertility that might otherwise decline with TRT alone.
Your protocol
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Suggested updates based on your monitored data
Bloodwork panel rechecked
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Frequently Asked Questions
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Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.
OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.
What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.
Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.
If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.
Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.
No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.
We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.
Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.
One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.
Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.
Here is why:
The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."
The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.
Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.
We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.
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