Biomarkers we prioritize on this medication
Confirms hypothalamic axis stimulation
View marker →Prevents hyperestrogenism, gynecomastia
View marker →Primary target, guides dose titration
View marker →Shapes how much testosterone is actually free
View marker →Stimulates red blood cell production
View marker →Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.
Medicine information
Enclomiphene is a selective estrogen receptor modulator that stimulates the body's natural testosterone production in men, supporting hormone balance, fertility, energy and metabolic health.
Commonly prescribed for
Active ingredients
Enclomiphene Citrate
An oral tablet. Store at room temperature. Your prescriber sets the strength and schedule. Changes in hormone levels are typically assessed on your next quarterly panel rather than by symptoms alone.
Enclomiphene is not an FDA-approved medication, so there is no approved label to cite and the reported effects come from clinical trials and from the wider experience with this class of estrogen receptor modulators. Reported effects include headache, hot flashes, irritability and mood changes, nausea, and acne. Less commonly reported are visual disturbances such as blurring, floaters or light sensitivity, which are described with this class and are treated as a reason to stop and be reviewed. Because the medication works by raising the body's own hormone signalling, effects related to higher estrogen — breast tenderness or gynaecomastia — are also reported. Long-term effects on bone, sexual function and body composition have not been adequately studied.
It is not appropriate for men whose low testosterone comes from a problem in the testicles rather than in the pituitary signal, because it works by increasing that signal. It is used cautiously or not at all with a history of blood clots, significant liver disease, or an untreated pituitary abnormality, and any new visual symptom is a reason to stop and be reviewed.
Enclomiphene is the trans-isomer of clomiphene citrate and functions as a selective estrogen receptor modulator (SERM). By competitively blocking estrogen receptors in the hypothalamus, enclomiphene prevents estrogen's negative feedback on the HPG axis. This leads to increased secretion of gonadotropin-releasing hormone (GnRH), which in turn stimulates the pituitary to release more luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Elevated LH then signals the Leydig cells in the testes to produce more testosterone, restoring levels through the body's own natural pathway. Unlike testosterone replacement therapy, enclomiphene preserves testicular function and sperm production, making it particularly valuable for men who wish to maintain fertility. Changes in testosterone, LH, and FSH are monitored through your OneTwenty quarterly lab panel.
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Frequently Asked Questions
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Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.
OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.
What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.
Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.
If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.
Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.
No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.
We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.
Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.
One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.
Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.
Here is why:
The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."
The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.
Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.
We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.
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