Biomarkers we prioritize on this medication

What a prescriber watches
while you're on it.

Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.

Medicine information

Everything about
Enclomiphene.

Enclomiphene is a selective estrogen receptor modulator that stimulates the body's natural testosterone production in men, supporting hormone balance, fertility, energy and metabolic health.

Commonly prescribed for

  • Low testosterone in men where preserving natural production and fertility is a priority
  • Secondary hypogonadism
  • An alternative to direct testosterone replacement

Active ingredients

Enclomiphene Citrate

Read more

Further reading on
Enclomiphene.

Your protocol

How OneTwenty
manages your protocol.

  1. 01 - At Start

    Baseline Labs

    Establish your starting point

  2. 02 - ongoing

    Connected Monitoring

    Weight + Device signals tracked

  3. 03 - Monthly

    Titration Updates

    Suggested updates based on your monitored data

  4. 04 - Quarterly

    Retest Biomarkers

    Bloodwork panel rechecked

Explore

More from the
OneTwenty formulary.

Longevity

Glutathione Injection

Glutathione Injections deliver the body's master antioxidant directly into the bloodstream to support detoxification, immune health and protection against oxidative stress.

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Longevity

Glutathione Nasal Spray

Glutathione Nasal Spray delivers the body's master antioxidant through the nasal mucosa to support detoxification, immune function and cellular protection.

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Mental Health

Oxytocin Nasal Spray

Oxytocin Nasal Spray delivers the body's natural bonding hormone through the nasal mucosa to support emotional connection, social confidence and stress resilience.

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Men's Health

HCG

HCG mimics LH to stimulate the testes, helping maintain natural testosterone production and fertility. Often used alongside TRT.

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Sexual Wellness

Sildenafil

Sildenafil is a fast-acting PDE5 inhibitor that increases blood flow to support firm, reliable erections when taken before sexual activity.

Learn more
Longevity

GHK-Cu Cream

GHK-Cu is a naturally occurring copper peptide applied to the skin. It is used in topical formulations for skin appearance and repair support.

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Sexual Wellness

Tadalafil

Tadalafil is a long-acting PDE5 inhibitor that increases blood flow to support firm, lasting erections, with effects that can last up to 36 hours.

Learn more
Sexual Wellness

PT-141

PT-141 is a melanocortin receptor agonist that acts on the brain to help increase sexual desire and arousal in both men and women.

Learn more
Men's Health

Enclomiphene

Enclomiphene is a selective estrogen receptor modulator that stimulates the body's natural testosterone production in men, supporting hormone balance, fertility, energy and metabolic health.

Learn more
Longevity

NAD+ Nasal Spray

NAD+ Nasal Spray delivers Nicotinamide Adenine Dinucleotide through the nasal mucosa for needle-free cellular energy support and cognitive function.

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Lifelong Optimization

Become a
Founding Member

Get started

Founding pricing ends at public launch

Frequently Asked Questions

Clarity before
you commit

Answers on setup, scale, and support to remove blockers.

What’s included in the membership?

Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.

Do you treat medical conditions?

OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.

What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.

Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.

If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.

Do you accept HSA and FSA?*

Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.

Do I have to take medications?

No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.

Is OneTwenty available in my state/country?

We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.

Is my health data secure? (HIPAA Standards)

Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.

What's included in my membership?

One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.

Why can't I use my insurance for these labs?

Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.

Here is why:

The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."

The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.

Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.

We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.

Didn't find your answer?

Ask it here. We reply by email, and the good ones end up on this list.

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