Biomarkers we prioritize on this medication
Sleep often improves as weight comes down
View marker →Direct read on primary issue you started this medication
View marker →GLP-1s commonly raise resting heart rate slightly
View marker →Glycemic response over ~3 months
View marker →Early read on metabolic shift
View marker →Cardiovascular risk as weight drops
View marker →Liver markers often improve with fat loss
View marker →Kidney function during appetite loss
View marker →Protects muscle while losing fat
View marker →Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.
Medicine information
Compounded Semaglutide is a GLP-1 receptor agonist that supports weight loss and metabolic health through appetite regulation and blood sugar control.
Commonly prescribed for
Active ingredients
Semaglutide
A weekly subcutaneous injection. Refrigerate on arrival and follow the pharmacy label for storage. Your prescriber starts you at a low dose and increases it over your first months. Appetite changes are usually noticed within the first few weeks. Digestive effects are most common early on and after each increase. Dispose of needles in a sharps container.
The most commonly reported effects are digestive: nausea, diarrhea, vomiting, constipation, indigestion and abdominal pain. These are dose-related and are reported most often in the first weeks and after each dose increase. Less common but more serious reported effects include pancreatitis, gallbladder disease including gallstones, dehydration and kidney injury after prolonged vomiting or diarrhea, allergic and injection site reactions, an increase in heart rate, and worsening of diabetic retinopathy in people with type 2 diabetes. Low blood sugar is reported mainly when this class is combined with insulin or a sulfonylurea. Semaglutide carries an FDA boxed warning for thyroid C-cell tumours based on rodent studies, and its labelling also flags the risk of stomach contents entering the lungs during general anaesthesia or deep sedation.
Semaglutide is not prescribed to anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, or with a known serious allergic reaction to semaglutide or any component of the formulation. It is not used in pregnancy, and labelling advises stopping it in advance of a planned pregnancy. It is not recommended in people with severe gastroparesis, and prescribers weigh it carefully against a history of pancreatitis, gallbladder disease, diabetic retinopathy, or reduced kidney function. Anyone scheduled for a procedure under anaesthesia or sedation should tell that team they are taking it.
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that mimics the effects of the naturally occurring GLP-1 hormone. By activating GLP-1 receptors in the pancreas, brain, and gastrointestinal tract, semaglutide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and signals the brain to reduce appetite and food intake. As your body weight decreases, key cardiometabolic markers—including HbA1c, fasting glucose, LDL, triglycerides, blood pressure, and BMI—all improve, which is reflected directly in your OneTwenty quarterly lab panel.
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Frequently Asked Questions
Answers on setup, scale, and support to remove blockers.
Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.
OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.
What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.
Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.
If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.
Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.
No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.
We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.
Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.
One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.
Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.
Here is why:
The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."
The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.
Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.
We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.
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