Biomarkers we prioritize on this medication
Glycemic response over ~3 months
View marker →Insulin resistance, where metformin act first
View marker →Long term metformin use reduces B12 absorption
View marker →Kidney function sets the safe dose
View marker →Liver markers often improve with metabolic gain
View marker →Low-grade inflammation tracks metabolic improvement
View marker →Direction is how the marker usually moves on this class of medication, not a target set for you. Once you are prescribed, your own values, ranges and trend appear in the app.
Medicine information
Metformin is an oral medication used to improve the body's response to insulin and lower blood sugar. It has been in clinical use for decades and is also studied for its effects on metabolic health.
Commonly prescribed for
Active ingredients
Metformin Hydrochloride
An oral tablet taken with food. Store at room temperature. Digestive effects are most common in the first weeks and often settle as your body adjusts. Your prescriber may adjust the dose over time based on your labs.
The most commonly reported effects are digestive: diarrhea, nausea, vomiting, abdominal discomfort, loss of appetite and a metallic taste. These are dose-related and reported most often when starting or increasing the dose. Long-term use is associated with lower vitamin B12 levels, which is why B12 is monitored on the panel. Metformin carries an FDA boxed warning for lactic acidosis, a rare but serious build-up of lactate in the blood that is more likely when kidney function is reduced, in acute illness with dehydration or low oxygen, with heavy alcohol use, and in significant liver disease. Symptoms are non-specific — unusual muscle aching, trouble breathing, unusual sleepiness, stomach pain with nausea — and warrant urgent medical attention.
Metformin is not prescribed to people with severely reduced kidney function (an eGFR below 30), to anyone in acute or chronic metabolic acidosis including diabetic ketoacidosis, or to anyone with a known allergy to metformin. It is generally paused around imaging studies that use iodinated contrast and around surgery, and it is used cautiously or not at all with significant liver disease, heavy or binge alcohol use, unstable heart failure, or any acute illness causing dehydration or low oxygen. Kidney function is checked before starting and at least yearly during treatment.
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Longevity Glutathione Injections deliver the body's master antioxidant directly into the bloodstream to support detoxification, immune health and protection against oxidative stress.
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Longevity Glutathione Nasal Spray delivers the body's master antioxidant through the nasal mucosa to support detoxification, immune function and cellular protection.
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Mental Health Oxytocin Nasal Spray delivers the body's natural bonding hormone through the nasal mucosa to support emotional connection, social confidence and stress resilience.
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Men's Health HCG mimics LH to stimulate the testes, helping maintain natural testosterone production and fertility. Often used alongside TRT.
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Sexual Wellness Sildenafil is a fast-acting PDE5 inhibitor that increases blood flow to support firm, reliable erections when taken before sexual activity.
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Longevity GHK-Cu is a naturally occurring copper peptide applied to the skin. It is used in topical formulations for skin appearance and repair support.
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Sexual Wellness Tadalafil is a long-acting PDE5 inhibitor that increases blood flow to support firm, lasting erections, with effects that can last up to 36 hours.
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Sexual Wellness PT-141 is a melanocortin receptor agonist that acts on the brain to help increase sexual desire and arousal in both men and women.
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Men's Health Enclomiphene is a selective estrogen receptor modulator that stimulates the body's natural testosterone production in men, supporting hormone balance, fertility, energy and metabolic health.
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Longevity NAD+ Nasal Spray delivers Nicotinamide Adenine Dinucleotide through the nasal mucosa for needle-free cellular energy support and cognitive function.
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Frequently Asked Questions
Answers on setup, scale, and support to remove blockers.
Your membership includes four targeted lab panels each year, continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, custom supplements, and access to prescription treatment through independent licensed providers, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.
OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.
What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.
Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.
If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.
Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.
No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.
We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.
Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.
One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.
Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.
Here is why:
The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."
The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.
Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.
We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.
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