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Medicine information
GHK-Cu is a naturally occurring copper peptide applied to the skin. It is used in topical formulations for skin appearance and repair support.
Commonly prescribed for
Active ingredients
GHK-Cu (Copper Tripeptide-1)
A topical cream applied to clean skin on the area being treated. Store at room temperature away from direct light unless the pharmacy label says otherwise. Wash hands after application. Skin changes are typically assessed over weeks rather than days.
There is no FDA-approved GHK-Cu product and no approved label to cite; published human data are limited and come mostly from small cosmetic and wound-healing studies. The effects reported are local and confined to where the cream is applied: redness, stinging or burning on application, itching, dryness or peeling, and a temporary blue-green tint from the copper. Allergic contact dermatitis is the reaction to be aware of — copper is a recognised contact allergen — and presents as a persistent itchy red rash in the treated area rather than the brief stinging that can follow application. Breakouts are reported when the cream is applied to acne-prone skin. Long-term human safety data, and data on how much copper is absorbed with repeated use over large areas, are limited.
GHK-Cu cream is not used by anyone with a known allergy to copper or to any component of the cream. It is applied to intact skin only, and is not used on open wounds, broken skin, burns, or the eyes and mucous membranes, and it is not applied over large areas of the body, because how much copper is absorbed that way has not been established. It is used cautiously or not at all in people with a disorder of copper handling such as Wilson's disease. It has not been studied in pregnancy or breastfeeding and is not used in either. There is no FDA-approved product, so this is a prescribing decision made by an independent clinician who has your history in front of them.
GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine) complexed with copper. Circulating levels are highest in early adulthood and fall substantially with age, which is part of why tissue repair slows over time. GHK-Cu acts as a signalling molecule: it carries copper into cells, influences the expression of genes involved in tissue remodeling, and stimulates fibroblasts to produce collagen, elastin, and glycosaminoglycans. Applied to the skin, that activity shows up as firmness, texture, and tone.
Topical application is the best-studied route for GHK-Cu, with human data from dermatological and cosmetic research. Systemic absorption through intact skin is limited, which is part of why it is generally well tolerated.
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