Globulin is a group of blood proteins that play key roles in immune function, inflammation, and transport within the bloodstream. It includes antibodies (immunoglobulins) as well as carrier proteins that help move hormones, lipids, and metals through the body. Unlike albumin, which reflects nutritional and liver status, globulin is more closely tied to immune activity.

In generally healthy individuals, globulin levels are useful as a broad signal of immune system engagement. Mild elevations can occur with chronic low-grade inflammation or immune activation, while lower levels may reflect reduced immune protein production or, less commonly, protein loss.