The short version
Superpower and Function Health are the two names people compare most, and in 2026 they look more alike than ever. Both run a big first draw and a follow-up later in the year. Both land north of 150 tests. Both explain the numbers in an app. Superpower is $349 a year, or $399 in New York and New Jersey. Function is $365.
The real differences are treatment and cadence. Function stops at the report. Superpower adds a marketplace to buy what the report suggests. OneTwenty, at $499, retests every quarter, pulls in your devices, and has licensed physicians run the protocol.
Testing: two draws, or four
Function Health leads on breadth. The first draw covers 100+ tests, and a second draw three to six months later rechecks 60+ of them. That is 160+ tests in a year, the widest menu here.
Superpower matched the two-draw model in 2026: about 90 metrics at baseline, then a follow-up draw that retests around 60. Call it 150+ tests across the year.
OneTwenty starts with a full baseline of 100+ markers and then retests every quarter. The retests are targeted: the markers that were out of range, the markers your protocol is trying to move, and anything your physician wants to watch. Over a year that adds up to about 200 results, each one a point on a trend line rather than a single reading.
Drawing blood: Quest or at home
All three send you to a Quest Diagnostics location by default. Superpower charges about $119 for an at-home draw. OneTwenty charges $99. Function does not offer one.
In New York and New Jersey, state rules limit consumer-initiated testing. Superpower prices those states at $399. OneTwenty runs on at-home draws there and prices the membership at $749.
What happens after the results
Function gives you results with clinician review and an action plan. It does not treat, prescribe, or act on the findings. The expectation is that you take the report to your own doctor.
Superpower pairs the action plan with a marketplace where prescriptions and supplements can be bought through partner providers. That is a real advantage over Function if you want to act inside the same app.
OneTwenty treats the results as the start of a protocol. A licensed physician reviews every panel. Where clinically appropriate, prescription treatment is available through independent licensed providers, from hormone optimization to thyroid support. Custom supplement packs are built from your panel. Then the next quarter’s retest tells you whether it worked.
Devices and daily data
A blood panel is a snapshot. Sleep, heart rate variability, resting heart rate, weight and blood pressure change every day, and they change first.
Superpower syncs with popular wearables and folds that data into its app. Function is a lab product first, and device data is not central to it.
OneTwenty connects your watch, ring or band, a smart scale and a blood pressure cuff, and reads them alongside your labs. Up to three months of history is pulled in when you connect. An AI health assistant watches the incoming data, answers questions, and flags anything that needs clinical attention.
Price, and what the price buys
Superpower is the cheapest of the three at $349. Function is $365. OneTwenty is $499, and $749 in New York and New Jersey. All three are HSA and FSA eligible.
The $134 to $150 gap between OneTwenty and the other two buys two extra draws, the device integrations, the AI assistant, and physicians who prescribe. If you only want the numbers, the other two are cheaper. If you want the numbers to change, that is what the gap pays for.
The honest case for each
If you want the most tests in one year and you already have a doctor you trust to act on them, Function Health is a strong choice.
If you want two draws a year at the lowest price and a menu of things to buy afterward, Superpower does that well.
If you want your numbers to improve rather than just be measured, and you want someone checking every quarter whether they did, that is what OneTwenty is for.


