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COMPARISON

Hone Health vs Marek Health and the third option

Hone Health is the cheap door into physician-managed TRT: a $65 at-home test, then $149 a month. Marek Health is the deep end: no membership, a $250 intake, and labs and visits priced individually. OneTwenty is the third option, a whole-body membership where hormones are one part of the protocol.

Updated September 7, 2026

At a glance Hone Health $65 assessment, then $149 / month At-home finger-prick assessment, then a monthly membership with quarterly testing and prescriptions billed separately. Marek Health No membership; pay per service Telehealth optimization clinic: a $250 intake, then labs and provider visits priced individually. $499 / year ($749 in NY and NJ) A full baseline, then quarterly retests, devices and a physician-backed protocol that keeps updating.
Annual price $65 initial assessment; Premium $149 / month, Plus $129 / month, Basic $25 / month $250 intake, then pay per lab panel and visit; guided programs from about $299 $499 / year, $749 in NY and NJ
Blood draws per year Every three months on Premium As prescribed; quarterly panels are typical on a protocol 4: a full baseline, then three targeted retests
Biomarkers 40+ per test 60 to 100+ per panel depending on tier; panels run $150 to $1,950 100+ at baseline, then the markers that moved, about 200 results a year
Where you get drawn At home, finger-prick kit Quest or Labcorp, walk-in Quest walk-in included, or at home for $99
Wearables and devices Basic biomarker tracking in the app Not central to the product Watch, ring, band, smart scale and BP cuff, all feeding one protocol
Doctor involvement Physician consults on Premium and Plus Telehealth providers plus a health coach Licensed physicians order and review every panel
Treatment TRT, clomiphene, anastrozole and more, billed separately by the pharmacy Full prescribing: TRT, thyroid, peptides and more, billed separately Prescriptions where appropriate, through independent licensed physicians, plus custom supplement packs
Between draws Care team messaging and protocol adjustments Health coach check-ins and protocol adjustments Daily device data, an AI health assistant, and a protocol that updates as numbers change
HSA and FSA Confirm with Hone Confirm with Marek Eligible

Prices and inclusions as published by each company, checked September 7, 2026. Plans change; confirm on their sites before buying. Sources: Hone Health review 2026, AccessNewswire , Hone Health review, TRT Plug , Marek Health review, TRTReady , Marek Health review, Vitality Scout

The short version

Hone and Marek are both telehealth clinics that prescribe testosterone and related therapies. Hone is built for volume: a $65 at-home finger-prick assessment, a physician consult, then a membership at $149 a month for quarterly testing and care, with medication billed separately. Marek is built for depth: a $250 intake, then lab panels from $150 to $1,950 and provider visits priced individually, with 60 to 100+ markers per panel and a health coach.

OneTwenty is not a hormone clinic. It is a longevity membership that includes hormone optimization where appropriate, alongside quarterly retests of 100+ markers, devices and supplement packs, for $499 a year.

Testing

Hone tests 40+ markers every three months on its Premium plan, from an at-home kit. Marek runs venous panels at Quest or Labcorp with the widest menus in this comparison, as prescribed by your provider. OneTwenty runs a 100+ marker baseline and three targeted quarterly retests, at Quest or at home for $99.

Doctors and treatment

All three involve physicians. Hone offers TRT in several forms, clomiphene and anastrozole. Marek offers the broadest prescribing, including TRT, thyroid and peptides, run by telehealth providers with a coach. OneTwenty’s physicians review every panel and prescribe where clinically appropriate through independent licensed providers, and the protocol also covers sleep, metabolic health and supplements, not hormones alone.

Devices

Hone tracks biomarkers in its app. Marek does not build around devices. OneTwenty connects a watch, ring or band, a smart scale and a blood pressure cuff and reads them alongside labs.

What it costs over a year

Hone Premium is about $1,850 a year including the assessment, before medication. Marek varies with the protocol; a standard TRT year with periodic labs commonly lands between $2,500 and $5,400. OneTwenty is $499 a year, or $749 in New York and New Jersey, with prescriptions paid to the pharmacy.

The honest case for each

If you want TRT managed by a physician for the least money up front, Hone.

If you want the deepest labs and a provider who will tune a complex protocol, and you are prepared to pay for it, Marek.

If hormones are one part of what you want to fix, and you want the rest of your biology retested every quarter too, OneTwenty.

Which one is right for you

Hone Health

Best if you want the cheapest door into physician-managed TRT and are fine with a smaller panel.

  • $65 at-home assessment to start
  • Quarterly testing on the Premium plan
  • Medication billed on top of the membership

Marek Health

Best if you already know you want a physician-run hormone or peptide protocol and want the deepest labs behind it.

  • Deepest lab menus per panel
  • Telehealth providers who prescribe
  • Costs add up: often $2,500 to $5,400 a year on TRT

Best if you want the numbers to keep moving, not just get measured.

  • Quarterly retests of what changed
  • Wearables, scale and BP cuff in one protocol
  • Physician-backed prescriptions and supplement packs
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Questions people ask

Are these prices current?

Prices are as each company publishes them, checked on the date at the top of this page. Clinic pricing changes often and medication costs vary by pharmacy, so confirm before you sign up.

Does OneTwenty prescribe testosterone?

Where clinically appropriate, yes, through independent licensed physicians. OneTwenty itself is not a medical practice. Hormone optimization is one part of a protocol that also covers sleep, metabolic health and nutrients.

Can I switch to OneTwenty mid-year?

Yes. A OneTwenty membership starts with its own baseline panel, so you do not need results from another service. If you have recent labs, you can upload them so your first protocol starts with history.

Is OneTwenty available in New York and New Jersey?

Yes. Because of state rules on lab draws, membership in New York and New Jersey is $749 a year and runs on two larger panels instead of four, with at-home phlebotomy.

The OneTwenty membership

$499/ per year

$749/ per year (NY/NJ Only)**

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FEATURES:

  • One Health Score that tells you exactly where you stand
  • Supplement protocol matched to your lab results
  • Syncs with your watch, ring, scale, BP cuff, and CGM
  • AI that reads your labs and device data — and tells you what actually matters
  • Medications and HRT available through licensed providers, guided by your data
  • Quarterly lab panels — your biomarkers tested and trended 4x a year

HSA/FSA Reimbursement Eligible*

HIPAA Security Standards

Lifelong Optimization

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Frequently Asked Questions

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Answers on setup, scale, and support to remove blockers.

What’s included in the membership?

Your membership includes four targeted lab panels each year (two larger panels in NY/NJ), continuous monitoring from the wearable device of your choice, and continuous monitoring of your smart scale to track weight and body composition. You’ll also receive access to our proprietary health scoring system, built on the American Heart Association’s Life’s Essential 8, which gives you a clear picture of your cardiovascular and metabolic health. Membership comes with ongoing support from a dedicated health coach, as well as convenient access to physician-guided prescription treatments and supplements, all managed directly through your dashboard. Additional devices and monitoring tools can be purchased at discounted member pricing.

Do you treat medical conditions?

OneTwenty is a health optimization membership, not a medical practice. We don't diagnose, treat, or cure medical conditions, and we don't practice medicine.

What we do is give you a clearer picture of your own health. Your membership includes quarterly lab testing, integration of your wearable data, and an AI-powered view of your biomarkers and trends over time. The focus is optimization and prevention for people who are generally healthy and want to stay that way, not the treatment of disease.

Anything clinical, including prescriptions, is delivered by independent, licensed healthcare providers through our telehealth partners. Those providers exercise their own medical judgment and are solely responsible for any evaluation, diagnosis, treatment, or prescription. OneTwenty does not direct or control their clinical decisions.

If you're managing a diagnosed condition, OneTwenty is not a substitute for your physician. We're a complement to the care you already receive, focused on helping you understand and improve the long-term inputs to your health.

Do you accept HSA and FSA?*

Most members can use HSA or FSA funds for their OneTwenty membership. Your membership covers diagnostic lab testing and clinician review, which are generally eligible medical expenses, though final eligibility depends on your specific plan. If you pay with an HSA/FSA card, it works like any other card at checkout. If you don't have a card, or your plan requires documentation, we provide an itemized statement listing the services, the ordering provider, and the amount paid, which you submit to your plan administrator for reimbursement. We can't guarantee your plan's decision, so we recommend confirming with your administrator.

Do I have to take medications?

No, OneTwenty prioritizes natural interventions that escalate over time. We will start with lifestyle modifications, then supplements, and only then if needed do we prioritize medication intervention.

Is OneTwenty available in my state/country?

We are available in 49 states except for Rhode Island. In New York and New Jersey, there is an increased fee due to collection laws in place that don't allow us to use the Quest Network.

Is my health data secure? (HIPAA Standards)

Your privacy and security are foundational to OneTwenty. We run on infrastructure and software built to HIPAA security standards, and we apply the same core safeguards used to protect data in regulated healthcare settings: encryption in transit and at rest, strict role-based access controls, and full audit logging of who accesses your information and when. We never sell your personal health data. You decide what you connect and share, and you can request deletion of your data at any time.

What's included in my membership?

One year on the OneTwenty platform, which covers four lab draws: one comprehensive initial panel to set your baseline, and three custom follow-up panels based on your results. Any additional services are available separately at transparent pricing.

Why can't I use my insurance for these labs?

Currently, we do not support direct insurance billing for lab orders. We made this decision to protect our members from unexpected and excessive costs.

Here is why:

The "Medical Necessity" Requirement: Insurance companies typically only cover lab tests that are tied to a specific illness or diagnosis code (ICD-10). Because many of our panels are proactive and focused on longevity (preventive wellness) rather than treating an active sickness, they are frequently rejected by insurers as "investigational" or "not medically necessary."

The Cost Risk: If we submitted these orders to your insurance and they were denied, the lab would bill you their standard "retail price." This retail price can be 5x to 10x higher than the negotiated rates we have secured for you.

Our Solution: By operating on a self-pay basis, we guarantee you access to our heavily discounted wholesale rates, ensuring you know exactly what you are paying upfront with no surprise bills in the mail later.

We are working on it: We understand that using insurance is preferred for basic labs. We are actively working on a solution that will allow us to safely bill insurance for standard preventive tests while keeping advanced longevity markers separate. We hope to introduce this hybrid option in the future.

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